buy you a drink



buy you a drink

gamma-Hydroxybutyric acid
Systematic (IUPAC) name
4-Hydroxybutanoic acid
Identifiers
CAS number591-81-1
ATC codeN01AX11
PubChem3037032
DrugBank?
Chemical data
FormulaC4H8O3 
Mol. mass104.10 g/mol (GHB)
126.09 g/mol (sodium salt)
142.19 g/mol (potassium salt)
Pharmacokinetic data
Bioavailability25% (oral)
Metabolism95%, mainly Hepatic, also in blood and tissues
Half life30 - 60 minutes
Excretion5%, renal
Therapeutic considerations
Pregnancy cat.

B

Legal status

Prohibited (S9)(AU) Schedule III(CA) Class C(UK) Schedule I(US) Class B (NZ)

RoutesUsually oral; intravenous

Gamma-Hydroxybutyric acid (4-hydroxybutanoic acid, C4H8O3), commonly abbreviated GHB, is a naturally-occurring substance found in the central nervous system, wine, beef, small citrus fruits, and almost all living creatures in small amounts. It is also a neuroprotective therapeutic drug that is illegal in a number of countries. It is currently regulated in the US and sold by Jazz Pharmaceuticals under the name Xyrem.

In a medical setting, GHB has been used historically as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance. It is also used illegally under the street names Juice, Liquid Ecstasy, Fantasy, "Georgia Homeboy", and simply G, either as an intoxicant or as a date rape drug. GHB is naturally produced in the human body's cells and is structurally related to the ketone body beta-hydroxybutyrate. As a drug, it is used most commonly in the form of a salt. GHB is also produced as a result of fermentation, and so is found in small quantities in some beers and wines.



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